The Odeon of Ephesus is located opposite the Basilica Stoa. An inscription on a part of the architrave indicates that the Odeon was donated in the 2nd century AD by the wealthy Father Vedius Antonius and his wife Flavia Papiana. The cavea is surrounded by a wall and supported by a substructure with barrel vaults. The Odeon could accommodate up to 1500 people. The rows of seats are divided into kerkides.

Above the cavea, there was a gallery with red granite columns, as is evidenced by architectural finds. Like Odeen and Bouleuterion, the building had a fixed roof. These roofs consisted of a wooden framework covered with clay tiles.